Drug Treatments for Heartworm Disease without Caval Syndrome
Melarsomine: This arsenical is the best adulticide option in a dog with heartworm disease (that is not in caval syndrome). The drug is given intramuscularly in 2 doses spread 24 hours apart. For dogs that are sicker and have a higher worm burden, one dose may be followed a month later with the standard 2 dose treatment. Rapid adult worm death in a dog with caval syndrome will cause death. Caparsolate is another arsenical which was used historically for adulticide, but melarsomine, with superior safety and efficacy, has replaced it.
Milbemycin: A microfilaricidal drug (500-999 mcg/kg) that may be used to kill microfilariae (usually 1 month post-adulticide). It may also be used as a preventative at the same dose when given once monthly during mosquito season.
Ivermectin: At 50 mcg/kg ivermectin (off-label basis) is a microfilaricidal drug that can be used 1 month post-adulticide. At 5-12 mcg/kg dose, ivermectin is used as a preventative. It is given once monthly.
|