Biomathematics Unit

University of Pennsylvania School of Veterinary Medicine | 382 West Street Road Kennett Square, PA 19348 | Phone: 610.444.5800

 

Current Projects
Diabetes & Glucose Metabolism

Using WinSAAM, clinical models for quantifying insulin action are used to investigate glucose metabolism.  A model is an hypothesis of set of hypotheses, containing a scientific statement regarding the system under invetigation.  A model incorporates pathways, process, pools, inputs and outputs and their integral role within the system.    Models are derived from system information and the data available and is used to reduce data to its simplest form enabling comparisons between individual sets of data, establishment of standard and references, and the comparison between the two.

Below are examples of two different models and their use within WinSAAM.

The Minimal Model of Glucose Disappearance

The purpose of this model is to provide a basis for estimating Insulin Sensitivty and Glucose Mediated Glucose Disposal, based on data obtained from Intravenous Glucose Tolerance Test.

Ref . Pacini & Bergman, 1986, MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the FSIGT. Comp. Meth, and Prog in Biomed; 23, pg 113-122. 
Ref. Bergman & cowden, The Minimal Model Approach to Quantification of Factors Controlling Glucose Disposal in Man; In Carbohydrate Metabolism, Chap 13, p 269-296.

Insulin action is achieved apropos to its delivery to a remote site.

Insulin in this remote site acts concurrently with glucose to dispose of glucose and the effect to these two factors can be resolved.

Glucose synthesis and disposal can be resolved by monitoring the response to a single assault to the system.

 

The Minimal Model for Glucose Kinetics

The purpose of this model is to enable the assessment of pancreatic responsiveness in first and second phase insulin secretion.

Ref . Pacini & Bergman, 1986, MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the FSIGT. Comp. Meth, and Prog in Biomed; 23, pg 113-122. 
Ref. Bergman & cowden, The Minimal Model Approach to Quantification of Factors Controlling Glucose Disposal in Man; In Carbohydrate Metabolism, Chap 13, p 269-296.

Insulin is released from the pancreas in direct response to plasma glucose above threshold level.

Insulin is lost at a rate proportinal to insulin level.

 Download a Demo version of our MINMOD Millennium program