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General & Systemic Pathology
General and Systemic Pathology
General Pathology
Systemic Pathology
Exam 3
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General and Systemic Pathology
General Pathology
Systemic Pathology
Exam 2
Respiratory
Genetic & Neonatal
Liver
Pancreas
Pancreas 2
Pancreas 3
Pancreas 4
Pancreas 5
Reproductive
Skin
Exam 4
Exam 3
Descriptive Terminology
Glossary
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Systemic Pathology
Exam 2
Pancreas
Pancreas 2
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2. What is the pathogenesis of pancreatic necrosis?
Check your answer
Insult/Injury (direct, toxin, hormone)
decreased zymogen secretion
accumulation of zymogen granules in pancreatic cells
fusion of lysosomes and zymogen granules
lysosomal hydrolases cleave trypsinogen
trypsin activation
activation of other zymogens
autodigestion (necrosis) of pancreas and surrounding tissues
blood vessel necrosis
thrombosis, hemorrhage, edema
further necrosis due to ischemia
fat necrosis + Ca
2+
fat saponification
inflammation
further necrosis due to neutrophilic enzymes
fibrosis
Pancreas 2
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Pancreas 3
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Pancreas 4
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Pancreas 5
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