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Poisonous Plants

Veratrum californicum or viride Minimize
CORN-LILY (Veratrum species)
CORN-LILY (Veratrum species)
CORN-LILY (Veratrum species)
CORN-LILY (Veratrum species)
CORN-LILY (Veratrum species)
CORN-LILY (Veratrum species)

Veratrum californicum or viride

WESTERN FALSE HELLABORE

Distinguishing features
Western false hellebore is a native perennial herb 1-8 feet tall, with erect, unbranched, very leafy stems; the leaves are broad, large, alternate and three-ranked, sheathing the stem, somewhat folded, strongly parallel veined. Flowers are in large panicles at top, white to greenish with the three sepals and three petals alike.
Description
Veratrum belong to the Liliaceae family and are broad-leaved perennials that grow from thick, fibrous rootstocks. They can attain a height of 6 to 8 feet under optimal growing conditions. The hairless leaves, which are often pleated, are alternate, clasping and parallel-veined. Numerous flowers are produced on branching terminal panicles or clusters. The star-shaped flowers of V. californicum are white in color; those of V. viridae tend to be pale green. The fruits are three-chambered capsules that contain numerous brown, winged, flat seeds.
Geographic Distribution
~ fifty species of Veratrum are distributed throughout Europe and NA. V. californicum and V. viridae are the most significant species in NA. Both grow in mountainous areas where moist or swampy conditions exist. V. californicum is usually restricted to altitudes above 5000 ft. in the mountains of western NA. V. viridae is more common in the eastern and southern regions of the continent.
Toxin
~ 60 toxic steroidal alkaloids have been isolated from Veratrum species. Many have potent hypotensive properties. Three of the alkaloids are teratogenic (jervine, cyclopamine and cycloposine).
Toxicity
45 grams of root/rhizome given twice daily for three days to ewes beginning on day 29 of gestation induced typical limb deformities in lambs.
MOTA
the mechanism of teratogenesis is believed to be related to defective chondrogenesis resulting from the inhibition of proteoglycan synthesis. Defective cartilage formation effectively induces malformations of the head, trachea and epiphyseal plates of the leg bones. Alternatively, it has been proposed that the teratogenecity of cyclopamine is related to its inhibitory effect on catecholamine release from cholinergic receptors in the embyronic neuroepithelium thus disrupting normal development.
Diagnosis
Clinical signs
manifestations of the teratogenic effects are directly related to the stage of gestation at which the plant is eaten. If pregnant ewes are exposed on the 14th day of gestation, lambs develop classic cyclopian deformities (monkey-faced lambs). Veratrum fed on the 17th and 18th days of gestation induced motor-nerve paralysis of the hindlegs of lambs. Other craniofacial deformities occur if Veratrum is fed to ewes between the 12th and 30th days of gestation (cleft palate, harelip and brachygnathia). Lambs can develop shortened legs as a result of hypoplasia of the metacarpal and metatarsal bones if ewes eat the plant between days 30 to 36. Tracheal stenosis has also been reported in fetuses from ewes fed V. californicum roots and rhizomes. Species other than sheep can also be affected. Affected lambs are often stillborn. Adult sheep are seldom directly affected by Veratrum but can succumb to hypotensive effects if enough is ingested. Dystocia can occur as a result of oversized fetuses induced by prolonged gestation and lamb malformations.
Laboratory
not useful
Lesions
typical fetal malformations
Treatment
not useful
Prevention
keeping animals away from Veratrum sp. during the first trimester of pregnancy has largely eliminated the problem in sheep.

Read more in the Poisonous Plants of Pennsylvania Publication

Effect on Animals Minimize
Lamb fetus.  Cyclops or "monkey- faced" lamb (Veratrum sp. ingested by ewe on day 14 of gestation).

Lamb fetus. Cyclops or "monkey- faced" lamb (Veratrum sp. ingested by ewe on day 14 of gestation).
Lamb with tracheal stenosis.

Lamb with tracheal stenosis.
Newly born cyclops lamb (plant ingested by ewe on day 14 of gestation).

Newly born cyclops lamb (plant ingested by ewe on day 14 of gestation).
Lamb with craniofacial abnormalities.

Lamb with craniofacial abnormalities.
Lamb with shortened metacarpals and metatarsals (ingested by ewe near day 30 of gestation).

Lamb with shortened metacarpals and metatarsals (ingested by ewe near day 30 of gestation).
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