Walter Flato Goodman Center for Comparative Medical Genetics

University of Pennsylvania School of Veterinary Medicine | 3800 Spruce Street Philadelphia, PA 19104-6008 | Phone: 215.590.7030

Grant Support

Research Grants

Faculty Grant Source Title
Aguirre NIH EY-13132 Models of linked Retinitis Pigmentosa
  NIH EY-06855 Models of hereditary retinal degeneration
  NIH EY-13729 Gene therapy for Lebers congenital amaurosis
  Fdn Fighting Blindness Retinal Degeneration Center
Atchison NIH GM-71830 PcG function of YY1 in transduction and development
Avadhani NIH GM-34883 Evolution & function of hepatic mitochondrial P-450
  NIH CA-22762 Mitochondria-to-nucleus stress signaling and cancer
  NIH GM-49683 Physiological regulators of Cyto-chrome Oxidase activity
Bennett NIH EY-17096 AAV- mediated gene correction in the retina
  NIH EY-10820 Gene therapy for inherited retinal degeneration
  Macula Vision Res Generation of animal models for Malattia
  Fdn- Rescue of retinal degeneration in animal models using adeno-associated virus (AAV)- Mediated delivery of rod-derived cell viabilitiy factor
  ITMAT Gene therapy for autosomal dominant polycycstic kidney disease
Brinster NIH HD-44445 Male germline stem cell culture and genetic modification
 
NIH AG-24992
 Aging of male germline stem cells
Cancro NIH AI-54488 Role of BLyS in peripheral B cell survival and selection
Casal NIH AR-49817 A canine model for human X-linked ectodermal dysplasia
  Irish Wolfhound Society Studies on epilepsy and primary ciliary dyskinesia
  APOXIS Recombinant EDA-A1 to treat of canine ectodermal dysplasia
  NORD A canine model for the Ehlers-Danlos syndrome
Dobrinski NIH RR-17359 Transplantation of testis stem cells in large animals
  NIH HD-44780 Transgenic goats produced by germ cell transplantation
Felsburg NIH AI-43745 Gene therapy for canine X-linked SCID
Fraser NIH NS-29390 Gene transfer to and expression in neurons in vivo
  NIH NS-33768 Mechanism of latency of herpes simplex virus
Haskins. NIH DK-25759 Animal models of mucopolysaccharidoses
  NIH DK-54481 Gene therapy in MPS VII
  NIH DK-66448 Retroviral vector-mediated liver gene therapy for MPS I
Henthorn NIH NS-41989 Molecular analysis of a canine CNS developmental defect
  Canine Health Fdn Molecular characterization canine cystinuria and carrier test
  NIH HL-18848 Etiology and development of congenital heart disease
High NIH HL-64190 Gene therapy for hemophilia
  NIH HL-74124 Biological roles of factors X and Xa
  NIH HL-78810 Immune responses to AAV-mediated F.IX Gene transfer
Hunter NIH A1-42334 Regulation of the early immune response to Toxoplasma gondii
  NIH AI-62789 Expression and function of TLRs on T cells
  NIH AI-71302 Role of dendritic cells in resistance to T. gondii
Koretzky NIH GM-53256 Novel substrates of the TCR kinase
  NIH A1-58019 Regulation of T cell and mast cell function by DGKzeta
  NIH CA-93615 Temporal and spatial organization of signaling complexes in T and B cells
  NIH A1-61039 Regulation of PMN activation by SLP-76, PRAM-1 and ADAP
Pearce NIH A1-32573 Schistosome egg induced Th2 responses
  NIH AI-53825 Dendritic cell function in schistosomiasis
Scott NIH AI-35914 Il-12 as an immunopotentiator in leishmaniasis
  NIH AI-59396 Vaccine development in leishmaniasis
Stedman NIH NS-42874 Surgical approaches to systemic gene transfer
  NIH NS-52476 Translational program for molecular therapeutics in DMD
  NIH HL-64190 Safety & efficacy of Intravas. Del. of AAV-F.IX to skeletal muscle
  NIH HL-83078 Translational studies in heart failure gene therapy
Sweeney NIH AR-35661 Myosin Isozymes in muscle
  NIH AR-48931 Structure and function of Myosin V1
  NIH AR-48868 Understanding and preventing disuse atrophy
  Muscular Dystr Assn Validation of MR imaging for clinical trails in muscular dystrophy
  NIH AR-51174 Integration and control of molecular motors
  NIH AR-52646 Modulation of muscle growth for the muscular dystrophies
  NIH AR-48565 Mechanisms of Processivity in Molecular Motors
  DOD- Duchenne muscular dystrophy translational research
Vite Ara Parseghian Fndn Evaluating treatment strategies for feline NPC disease
Wilson NIH HL-59407 DNA viruses as vectors for cardiovascular diseases
  NIH HL-51746 AAV vectors based on new serotypes novel
  NHLBI HHSN2682007 Gene therapy resource program
  CFF R881-CR07 RDP COMP II
  Glaxo Smith-Kline Creation of vector systems for gene therapy
Wolfe NIH NS-56243 Stem cell transplantation for neurogenetic disease
  NIH NS-38690 AAV vector gene therapy for the CNS in MPS VII
  NIH DK-63973 Gene transfer & NMR studies in alpha -mannosidosis brain

 

Center and Facility Grants

Faculty Grant Source Title
Bennett FFB Center Grant Center for pediatric retinal degeneration
Haskins NIH RR-02512 Referral Center - Animal models of human genetic disease
Wilson NIH DK-47757 Gene therapy for CF and other genetic diseases
Wolfe NIH RR-21332 Biosafety for cats and dogs in models of human disease
  NIH RR-24134 Comparative Animal Biology

 

Training Grants

Faculty Grant Source Title
Atchison NIH RR-07065  Short term training: students in health professional schools
Cancro NIH A1-55428  Training in immune system
Fraser NIH AI-07324 Training in virology
High NIH HL-07150 Pediatric hematology research training program
Wolfe NIH RR-07063 Training in comparative medical & molecular genetics
  NIH DK-07748 Gene therapy training: CF and genetic diseases